Effects of 6-Hydroxydopamine on the Canine Sinus Node
نویسندگان
چکیده
منابع مشابه
Effects of 6-hydroxydopamine on the canine sinus node.
The acute effects of 6-hydroxydopamine (6-OH-DA) injected directly into the sinus node artery were studied in 57 dogs. The positive chronotropic effect of 6-OH-DA was intermediate between that of norepinephrine and that of tyramine, when these substances were compared on the basis of their ED 50. The increase in heart rate produced by 6-OH-DA was inhibited by prior intranodal injection of propr...
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15 صفحه اولA comparison of the effects of 5- and 6-hydroxydopamine on the isolated canine saphenous vein.
We studied and compared the effects of 5- and 6-hydroxydopamine (5- or 6-OHDA) on venous tone and on adrenergic and nonadrenergic responses of the isolated canine saphenous vein. In the tissue bath, both 5- and 6-OHDA caused increases in tone and abolished adrenergic responses to transmural nerve stimulation. Effects of 6-OHDA were blocked by desmethylimipramine. 6-OHDA reduced norepinephrine l...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1971
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.28.2.188